Abstract
For the prevention and treatment of gastrointestinal diseases, the microbiome of the living organism is of great importance. The human health depends on quantitative and qualitative composition of microbiota. Under the influence of factors of internal and external environment there is a change in the indigenous microflora. For correction, prevention and regulation of intestinal microbiocenosis within the framework of the biotechnology program, biologically active additive (BAA) is proposed, the main components of which are selective biomass bacteria, prebiotics, peptide ultralisates. As substances that perform the function of coenzymes, thiamine (vitamin B1) and pyridoxine (vitamin B6) are used in the production of this additive. The novelty of the technology is the composition and structure of solid gelatin capsules, ensuring maximum safety of biologically active ingredients and delivery of them to cells. Regulated quality indicators have been established. Sanitary-hygienic and sanitary-toxicological indicators of the BAA comply with the requirements of TR CU 021/2011 “On safety of food products”. Clinical approbation of the developed additive was carried out by volunteers with detected disorders of intestinal microbiota. BAA was taken 1 capsule 2 times a day in conjunction with other drugs regulating bowel biocenosis. At the end of dietary therapy, the microbiota recovery was observed in 90% of cases. Technical documentation has been approved for the new product, recommendations for application have been developed.
Highlights
The microbiome is of great importance in the processes of the organism's functioning
A promising way in the prevention, correction and regulation of intestinal microbiocenosis is the use of prebiotics of non-microbial origin that stimulate the growth of normal microflora
Living microcapsulated forms of probiotics, prebiotics and production samples of biologically active additive (BAA), representing the biotechnology program correction of indigenic bowel microflora were used as subjects of the research
Summary
The microbiome is of great importance in the processes of the organism's functioning. This group includes dietary fibers (cellulose, inulin, hemicellulose, pectins), oligosaccharides of various origins, poly- and oligofructans, other numerous substances and compounds produced by biotechnological and chemical synthesis. Prebiotics are sources of available microflora carbohydrates as the main nutrient material [5,7]. One such prebiotic is inulin, in enzymatic decay of which short-chain fatty acids are formed, providing the bowel microbiota with energy and protecting it from inflammatory processes [9, 10]
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