Scientific Evidence of Xuebijing Injection in the Treatment of Sepsis.

Sa Tian,Huiming Li,Xingzhan Zhang,Qian Niu,Shuguang Chen,Huawei Yang,Tao Liu,Luming Hu,Yixuan Ye,Defang Qin,Dejan Stojkovic

doi:10.1155/2021/6879278

Abstract

Objectives To systematically collate, appraise, and synthesize the current evidence on the Xuebijing injection (XBJI) for sepsis. Methods Eight databases were searched for systematic reviews (SRs) or meta-analyses (MAs) on XBJI for sepsis. Assessing the Methodological Quality of Systematic Reviews-2 (AMSTAR-2), Preferred Reporting Item for Systematic Reviews and Meta-Analyses (PRISMA), and Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) methods were used to assess the methodological quality, reporting quality, and evidence quality of the enrolled studies, respectively. Results Out of the 13 studies that were included, all studies were rated critically low quality based on AMSTAR-2 results. Based on the results obtained from PRISMA, all studies were reported to be over 80%, while the GRADE system yielded three outcome measures rated high-quality, 16 were of moderate quality, and the rest were of low or critically low quality. Conclusions The combination of XBJI and Western medicine (WM) showed significant synergy for the treatment of sepsis compared to WM alone. However, this conclusion should be treated with caution since the quality of the SRs/MAs providing the evidence was relatively low.

Highlights

Sepsis is a severe complication resulting from severe infection, severe trauma, burns, surgery, and shock. is complication is quite perilous, leading to septic shock and multiple organ dysfunction syndromes [1]
Conclusion summary e Xuebijing injection (XBJI) and ulinastatin combination therapy appeared to be more effective for the treatment of sepsis when compared with the use of ulinastatin alone. is study suggested that supplementation with XBJI in addition to the conventional treatment appeared to be more effective for the treatment of sepsis as compared to the conventional treatment alone. e combination therapy appeared to be more effective for the treatment of sepsis compared to the conventional treatment alone
Our results found that XBJI when combined with ulinastatin was superior to both routine therapies and the single administration of either ulinastatin or XBJI. e combination therapy appeared to be more effective for the treatment of sepsis when compared to conventional treatment alone. is study suggested that supplementation with XBJI in addition to the conventional treatment appeared to be more effective for the treatment of sepsis as compared to conventional treatment alone. e utilization of XBJI has a certain effect on the improvement of the inflammatory response and increased level of platelets. e homogeneity of the reduced mortality rate and the available evidence was sufficient to support the use of XBJI as adjunctive therapy for sepsis

Summary

Introduction

Sepsis is a severe complication resulting from severe infection, severe trauma, burns, surgery, and shock. is complication is quite perilous, leading to septic shock and multiple organ dysfunction syndromes [1]. Sepsis is a severe complication resulting from severe infection, severe trauma, burns, surgery, and shock. Is complication is quite perilous, leading to septic shock and multiple organ dysfunction syndromes [1]. Despite the major advances in antibiotics and supportive therapies over the last few decades, mortality from sepsis still maintains an increasing trend [5]. There is still no effective treatment for sepsis. Conventional anti-infection and supportive therapies have shown no significant improvement in the survival rate of patients with sepsis [6, 7]. Under these circumstances, complementary and alternative therapies have drawn attention

Objectives

Results

Conclusion