Abstract
This 1993 AABT presidential address offers a brief survey of some factors associated with schizophrenia and bipolar disorder. Highlighted are findings regarding the influence of biological, psychological and cultural factors. The magnitude of the influence of biological factors is illustrated in research on morbidity risk, twin concordance, chromosome localization, brain glucose metabolism, ventricle size, smooth eye movement impairment, and dopamine function. The psychological evidence that is presented emphasizes the data on Expressed Emotion (EE) and includes discussion of cross-cultural research findings. The article concludes with the position that research on origins and influences must examine multiple factors, and offers an attempt to integrate the various findings.
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