Abstract
Previous investigators have provided radioimmunological and immunocytochemical evidence for an enkephalinergic (opioid) system in Planaria and described naloxone-sensitive qualitative behavioral responses to κ-opioid receptor agonists. We report the application of Schild-analysis to the antagonism of a selective κ agonist (U-50,488H) by a selective κ antagonist ( nor-BNI) in a quantitative in vivo endpoint. The results provide further evidence of a κ-opioid-like receptor in planarians.
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