Abstract
It has been considered that, in the preclinical drug assay, punishment experiment is one of the best methods to evaluate an anti-anxiety property of psychotropic drugs. Many groups (1–7) have reported that anti-anxiety drugs increase the punished responding. In the punishment experiment, differences of the experimental situations, such as schedule programming, reinforcer and drug experience of the experimental animal etc . may affect the change of punished responding after the drugs. However, few systematic studies concerning these basic methodological problems have been done. In the present work, we examined the effect of diazepam on the three types of conditioned response-suppression which were produced under the fixed ratio (FR30) schedule of food and/or water reinforcements.
Published Version
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