Abstract
We have investigated the coulostatic immobilization of DNA to a chemically modified gold surface. The chemical modification involves the covalent attachment of chemically polarizable groups by reaction of thiols and disulfides with clean gold surfaces. We have determined that chemically modified surfaces possessing pendant cationic groups bind DNA. In this paper we report the reliable and reproducible scanning tunneling microscopy (STM) imaging of DNA using a gold surface chemically modified with N,N,-dimethyl-2-mercaptoethylamine and present the first STM images of an entire genetically functional DNA molecule, the circular plasmid pBS+.
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Schedule a callMore From: Journal of Vacuum Science & Technology A: Vacuum, Surfaces, and Films
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