Scandium Triflate-Catalyzed Nucleophilic Additions to Indolylmethyl Meldrum’s Acid Derivatives via a Gramine-Type Fragmentation: Synthesis of Substituted Indolemethanes

Abstract

Treatment of indolylmethyl Meldrum's acids with catalytic scandium triflate and a variety of nucleophiles results in the nucleophilic displacement of the Meldrum's acid moiety via a gramine-type fragmentation. The reaction is useful for the generation of heterocyclic compounds of significant molecular complexity.