Abstract
Background: Myanmar has one of the largest malaria burdens in the Greater Mekong Subregion (GMS). Throughout the GMS, Plasmodium falciparum parasites are increasingly resistant to artemisinin combination therapies. Given that there are no current alternative treatment therapies, one proposed solution to the threat of untreatable P. falciparum malaria is to eliminate the parasite from the region. Several small-scale elimination projects have been piloted in the GMS, including along the Myanmar-Thailand border. Following the success of the pilot elimination project along the Myanmar-Thailand border, there was a scale up to a broad area of Eastern Kayin State, Myanmar. Here we describe the establishment of the scale up elimination project in Easter Kayin State. Methods: The scale up relied on geographic reconnaissance and a geographic information system, community engagement, generalized access to community-based early diagnosis and treatment, near real-time epidemiological surveillance, cross sectional malaria prevalence surveys and targeted mass drug administration in villages with high prevalence of P. falciparum malaria. Molecular markers of drug resistance were also monitored in individuals with symptomatic and asymptomatic infections. Discussion: This protocol illustrates the establishment of an elimination project and operational research in a remote, rural area encompassing several armed groups, multiple political organizations and a near-absent health care infrastructure. The establishment of the project relied on a strong rapport with the target community, on-the-ground knowledge (through geographic surveys and community engagement), rapid decision making and an approach that was flexible enough to quickly adapt to a complex landscape. The elimination project is ongoing, now over three years in operation, and assessment of the impact of this operational research will follow. This project has relevance not only for other malaria elimination projects but also for operational research aimed at eliminating other diseases.
Highlights
Malaria is endemic in Myanmar and the Greater Mekong Subregion (GMS) and it is a major cause of morbidity
The impact of the interventions are monitored through the analysis of observational data collected through longitudinal passive case detection at community-based malaria diagnosis and treatment centers (malaria posts (MPs)) and through cross-sectional blood screenings conducted in targeted villages
The key interventions of the project included the establishment of a dense network of community level early malaria diagnosis and treatment clinics (MPs) and targeted mass drug administration (MDA)
Summary
Malaria is endemic in Myanmar and the Greater Mekong Subregion (GMS) and it is a major cause of morbidity. The results indicated that the strategy is safe and effective in rapidly eliminating the sub-microscopic reservoir of malaria parasites and in reducing transmission to mosquito vectors[12] These encouraging results motivated a scale up of the elimination project to much of Eastern Kayin State, Myanmar. The impact of the interventions are monitored through the analysis of observational data collected through longitudinal passive case detection at community-based malaria diagnosis and treatment centers (malaria posts (MPs)) and through cross-sectional blood screenings conducted in targeted villages. This protocol helps to fill an important gap in the literature on operational research programs aimed at eliminating malaria[13,14,15]
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