Abstract

BackgroundMass drug administration (MDA) has received growing interest to accelerate the elimination of multi-drug resistant malaria in the Greater Mekong Subregion. Targeted MDA, sometimes referred to as focal MDA, is the practice of delivering MDA to high incidence subpopulations only, rather than the entire population. The potential effectiveness of delivering targeted MDA was demonstrated in a recent intervention in Kayin State, Myanmar. Policymakers and funders need to know what resources are required if MDA, targeted or otherwise, is to be included in elimination packages beyond existing malaria interventions. This study aims to estimate the programmatic cost and the unit cost of targeted MDA in Kayin State, Myanmar.MethodsWe used financial data from a malaria elimination initiative, conducted in Kayin State, to estimate the programmatic costs of the targeted MDA component using a micro-costing approach. Three activities (community engagement, identification of villages for targeted MDA, and conducting mass treatment in target villages) were evaluated. We then estimated the programmatic costs of implementing targeted MDA to support P. falciparum malaria elimination in Kayin State. A costing tool was developed to aid future analyses.ResultsThe cost of delivering targeted MDA within an integrated malaria elimination initiative in eastern Kayin State was approximately US$ 910,000. The cost per person reached, distributed among those in targeted and non-targeted villages, for the MDA component was US$ 2.5.ConclusionThis cost analysis can assist policymakers in determining the resources required to clear malaria parasite reservoirs. The analysis demonstrated the value of using financial data from research activities to predict programmatic implementation costs of targeting MDA to different numbers of target villages.

Highlights

  • Mass drug administration (MDA) has received growing interest to accelerate the elimination of multidrug resistant malaria in the Greater Mekong Subregion

  • We explored the programmatic cost of targeted MDA implemented by Malaria Elimination Task Force (METF) in Kayin State, which covers 365,000 people

  • It is designed to be used in concert with detailed knowledge of the target area and/or with mathematical models that can simulate the impact of various strategy designs on the prevalence and incidence of malaria [37]. This cost analysis quantifies the costs of accelerating P. falciparum malaria elimination

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Summary

Introduction

Mass drug administration (MDA) has received growing interest to accelerate the elimination of multidrug resistant malaria in the Greater Mekong Subregion. The potential effectiveness of delivering targeted MDA was demonstrated in a recent intervention in Kayin State, Myanmar. This study aims to estimate the programmatic cost and the unit cost of targeted MDA in Kayin State, Myanmar. In 2010, the World Health Organization (WHO) proposed mass drug administration (MDA) as a strategy to accelerate the elimination of multi-drug resistant P. falciparum malaria [4]. This strategy aims to treat every individual in a community with three rounds of a full dose of antimalarial drug, regardless of whether they have malaria symptoms. A trial MDA conducted in Zanzibar showed no impact on malaria incidence [6]

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