Abstract
AbstractAn SbCl3-initiated Csp3 –Csp3 coupling between N-aryltetrahydroisoquinolines and nitromethanes was realized through the aerobic oxidation of sp 3 C–H bond, providing a series of nitromethylated tetrahydroisoquinoline derivatives in high yields. The results exhibited that SbCl3, as a cheap and commercially available reagent, is an efficient initiator to promote the direct functionalization of sp3 C–H bond with broad functional group tolerance, which is potentially applied to a wider range of C–H bond activation reactions.
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