Abstract
The reaction between the biologically active acids probenecid (HO2CC12H18NO2S), indomethacin (HO2CC18H15ClNO2) and sulindac (HO2CC19H16FOS) with Ru3(CO)12, followed by addition of axial ligands (L), such as pyridine, triphenylphosphine, or 5-(4-pyridyl)-10,15,20-triphenylporphyrin, generates a series of stable diruthenium tetracarbonyl complexes of the formula Ru2(CO)4(μ2-η2-O2CC12H18NO2S)2L2, Ru2(CO)4(μ2-η2-O2CC18H15ClNO2)2L2 and Ru2(CO)4(μ2-η2-O2CC19H16FOS)2L2, respectively. The molecular structure of 1a · C6H6 was solved by single-crystal X-ray structure analysis and a typical diruthenium tetracarbonyl backbone bridged by the carboxylato ligands and two axial triphenylphosphine ligands was revealed. The benzene molecule sits between two probenecid units, and is involved in π-stacking interactions with the aromatic part of probenecid. Despite the presence of biologically relevant derivatives and carbonyl groups within the sawhorse-type dinuclear complexes, all systems show no cytotoxicity towards human cancer cells, presumably due to the high lipophilicity of these neutral complexes.
Published Version
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