Abstract
Apoptosis, necroptosis, autophagy, and ferroptosis are distinct mechanisms of cell death. In this issue of Cell Chemical Biology, Magtanong etal. (2019) demonstrated that exogenous monounsaturated fatty acids (MUFAs) induce a ferroptosis-resistant cell state by suppressing the accumulation of lipid peroxides and decreasing levels of oxidizable polyunsaturated fatty acids (PUFAs).
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