Abstract
SATB1 Makes a Splash in T Cell Wnt Signaling
Highlights
For microbial invaders to establish an infection, they must overcome the defenses mounted by one of the body’s staunchest defenders, the T cell
In order to mount an effective immune response, T cells of all kinds must be able to recognize foreign invaders while ignoring body-derived materials. Before they differentiate into cytotoxic T cells or Th cells, immature T cells go through a series of checkpoints to ensure they fulfill these requirements
First characterized in flies as a mutation that impairs thoracic segment development, Wnt signaling works in all organisms; when soluble Wnt proteins bind to their receptors on cells, they initiate a signaling cascade that results in the accumulation of the protein b-catenin in the cells’ nucleus
Summary
For microbial invaders to establish an infection, they must overcome the defenses mounted by one of the body’s staunchest defenders, the T cell. SATB1 Makes a Splash in T Cell Wnt Signaling One of these support signals is provided by Wingless (Wnt) proteins.
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