Abstract
Acute kidney injury (AKI) is a common complication of all major surgery, which increases short- and long-term morbidity and mortality in patients. There is experimental and clinical evidence that renal tissue hypo-perfusion and/or hypoxia occurs during major surgery, which may contribute to the development of AKI. Yet, the relative effects of volatile and intravenous anaesthesia on global and regional kidney perfusion and oxygenation remain unclear. Accordingly, we compared systemic haemodynamic variables, renal blood flow (RBF), renal oxygen delivery (RDO2) and consumption (RVO2), renal cortical and medullary tissue perfusion and oxygen tension (PO2), and renal sympathetic nerve activity (RSNA) during volatile or intravenous anaesthesia and compared the findings with those in the non-anaesthetised state on post-operative Day 3.
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