Abstract
The unprecedented, real-life pressures of the COVID-19 pandemic have shone a harsh spotlight onto long held assumptions from medical research, not least in the field of human immunology. Faced with this unprecedented global dataset of human infection and immunity, it has become crucial to appraise and reappraise assumptions about the nature and measures of protective immunity, durability of antiviral immunity, and changes in immunity across the life course. The learning curve has been steep. At the start of the pandemic, there were opposing arguments.
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