SARS-CoV-2 and mutation RT-qPCR test positivity correlation with ABO and Rh blood types.

Abstract

Studies show that there may be a relationship between ABO blood type and SARS‐CoV‐2 transmission. It was aimed to determine by investigating the blood type of patients whose one‐step reverse transcription and real‐time polymerase chain reaction (RT‐qPCR) test were positive for SARS‐CoV‐2. ABO and Rh blood types of individuals whose RT‐qPCR test was positive for SARS‐CoV‐2 were examined and an evaluation was made to identify whether there was a relationship between them or not. The blood type data of 44.928 SARS‐CoV‐2 positive RT‐qPCR test results have been obtained. 17.656 (39.29%) were delta, 8048 (17.91%) were alpha, 800 (1.78%) were beta, and 3000 (6.67%) were omicrons while 15.424 (34.33%) SARS‐CoV‐2 positive mutation was found to be negative. Our study suggests that O and Rh (−) blood types may provide protection against delta, AB and Rh (+) blood types may hinder omicron infection while A and Rh (+) blood types may be more vulnerable to alpha and delta while B and Rh (+) are more sensitive to beta mutation. The molecular mechanism underlying the relationship between blood types and SARS‐CoV‐2 infection needs further molecular studies and multi‐centered studies.