Sarcopenia is associated with neoplasm of bone and articular cartilage: findings from Mendelian randomized study.

Abstract

Objective Exploring the causal relationship between sarcopenia and neoplasm of bone and articular cartilage by bidirectional Mendelian randomization Methods Genome-wide association study (GWAS) data on sarcopenia-associated traits including appendicular lean mass, low handgrip strength (including criteria from the European Working Group on Sarcopenia in Older People (EWGSOP) and the Foundation for the National Institutes of Health (FNIH)), and usual walking speeds were obtained from the UK Biobank (UKB). GWAS data for neoplasm of bone and articular cartilage( benign and malignant) were provided by the Finnish Genetic Database (FINNGEN). Three different methods of MR analysis: including Inverse-variance weighted (IVW), Mendelian randomized Egger regression (MR-Egger), and weighted median methods were utilized. Result MR analysis showed that high appendicular lean mass was positive associated with the risk of developing benign neoplasm of bone and articular cartilage (odds ratio (OR) and 95% confidence interval (CI) = 1.236(1.026,1.489), P =0.025)). At the same time there is no statistically significant association was found of traits related sarcopenia to malignant neoplasm of bone and articular cartilage. There were also no reverse causal correlation between neoplasm of bone and articular cartilage and traits related sarcopenia. Conclusions In European populations, better appendicular lean body mass is positively associated with the risk of benign neoplasm of bone and articular cartilage, representing the possibility that sarcopenia may be a protective factor against neoplasm of bone and articular cartilage.