Sarcocinerenoids A—J, Eight Rare Capnosane‐Type and Two New Cage‐Type Cembranoids with Promoting Angiogenesis Activity from the South China Sea Soft Coral Sarcophyton cinereum

Abstract

Comprehensive SummaryEight rare capnosane‐type cembranoids, sarcocinerenoids A—H (1—8) and two new cage‐type cembranoids sarcocinerenoids I—J (9—10) were isolated from the soft coral Sarcophyton cinereum. The 5/11 bicyclic carbon skeleton is the same in Sarcocinerenoids A—H (1—8), and they collocate distinctive oxygen rings. Sarcocinerenoids I—J (9—10) with a cage‐type structure have been discovered to have an oxygen bridge and an uncommon seven‐membered ring. Extensive spectroscopic investigation, X‐ray diffraction analysis, estimated ECD, and DP4+ probability assessments were used to ascertain the structures of the two types of diterpenoids. Moreover, compounds 1, 4 showed promoting angiogenesis activity in zebrafish assays.