Abstract
Epilepsy is a disease which causes neuronal damage and loss of consciousness in consequence of recurrent seizures. Nitric oxide as a neuromodulator in brain is a gas which can penetrate into cells. It has a significant role on physiological cases,pathology of many diseases such as inflammation and degenerative diseases. The purpose of this research is to search the activity of NO/cGMP pathway of valproic acid in an experimental acuteepileptic model which is induced with pentylenetetrazol in rats.18 adult male Wistar Albino rats were used in the study. The rats were randomly divided into 3 groups (n=6) as control group, pentylenetetrazol (PTZ+salin) 45 mg kg-1, valproic acid (PTZ+VPA) 150 mg kg-1. After 24 hours of PTZ application, all rats brain tissues were removed and then cortex and hippocampus were separated. While PTZ increased the hippocampus and cortex NO/cGMP levels compared to control (p <0.01), VPA decreased the hippocampusand cortex NO levels by comparison with PTZ (p <0.001). On the other hand, while VPA decreased cortex cGMP levels (p<0,05) it did not change cGMP levels in hippocampus (p> 0.05). This study has suggested that VPA can show antiepileptic activity via NO/cGMP pathway.
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