Abstract
Background and Objectives: Drugs hepatotoxicity is one of the most prevalent problems seen in medical practice. Many medications are linked to hepatotoxicity, including acetaminophen, tamoxifen and sodium valproate (VPA). The objective of this study is to investigate the preventive impact of silymarin (SIL) and /or vitamin C (Vit.C) on hepatotoxic Sodium Valproate in albino Rats. 
 Methods: Thirty adult male albino rats were divided equally into six groups; group (I): normal control, group (II): VPA 700 mg/kg, group (III): VPA + SIL 50 mg/kg, group (IV): VPA+ Vit.C 50 mg/kg and group (VI): VPA + SIL +Vit.C, VPA. The animals were killed after 14 days, and livers were taken for histological and biochemical analysis.
 Results: After 14 days, animals were sacrificed, and livers were collected for histopathologic examination and biochemical assessment. VPA group exhibited a significant increase in serum alanine aminotransferase and aspartate aminotransferase. Liver sections showed loss of normal pattern of hepatocytes, inflammatory infiltration, congested central vein and fatty infiltration. Each of ascorbic acid and silymarin partially improved the histological pattern of the liver. When they were combined together, they depict marked improvement in the measured parameters and showed normal liver sections.
 Conclusion: silymarin (SIL) and /or vitamin C (Vit.C) has hepatoprotective effects against VPA induced toxicity on liver.
Highlights
Within the human body, the liver is the largest organ
Often known as "vitamin C," is a well-known vitamin found in a variety of fruits and vegetables [14]
Because of there was no study examined the effect of silymarin and / or vitamin C on hepatotoxicity induced by Sodium Valproate, the objective of the current study is to investigate the preventive impact of silymarin and / or vitamin C on hepatotoxic of Sodium Valproate in albino Rats
Summary
The liver is the largest organ. It supports nearly every other organ in the body by performing metabolic, synthetic, and excretory activities. Ascorbic acid has an important physiological role in cells as a reducing agent, antioxidant and free radical scavenger [15]. Ascorbic acid reduces hepatic injury in an experimental model of acute ischemia in rats [17]. Many medications are linked to hepatotoxicity, including acetaminophen, tamoxifen and sodium valproate (VPA). The objective of this study is to investigate the preventive impact of silymarin (SIL) and /or vitamin C (Vit.C) on hepatotoxic Sodium Valproate in albino Rats. Each of ascorbic acid and silymarin partially improved the histological pattern of the liver. When they were combined together, they depict marked improvement in the measured parameters and showed normal liver sections. Conclusion: silymarin (SIL) and /or vitamin C (Vit.C) has hepatoprotective effects against VPA induced toxicity on liver
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