Abstract
Abstract Sampling and sample handling are crucial steps in monitoring and control of bioprocesses. Reproducibility in sampling and handling of the sample are key issues when developing new analytical tools. One of the problems with biotechnological processes is that often, microorganisms or enzymes are present in the sample and their activities have to be stopped in the sampling moment, otherwise the composition of the sample may change before analysis is carried out. Integrated processing of samples can be carried out using flow‐injection analysis with different processing steps such as dialysis, dilution, reagent addition etc. This area is attracting increasing interest now when industrial biotechnology is addressing processes with relatively low margins and where efficient process technology is a prerequisite.
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