Abstract

Binomial trial sample size specification depends upon the values of the unknown response rate parameters, as well as upon the size and power of the resulting test. In practice, the values assumed for these parameters are based upon the results of previous or pilot trials, or upon the investigator's prior knowledge or belief. In either case, there is some uncertainty associated with these values that should be taken into account if the sample sizes are to be specified realistically. This paper describes a procedure for incorporating this uncertainty explicitly into the sample size determination on the basis of joint confidence distributions obtained from the pilot or prior information.

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call

Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.