Abstract

Abstract : This is a lung cancer biomarker development project to test the hypothesis that there are discriminatory miRNA and proteomic biomarkers in saliva that can detect lung cancer with the aim to reduce the number unnecessary diagnostic workups (bronchoscopy) in patients with suspicious chest symptoms. Preliminary data is in place to support that our salivary biomarker technologies can discover and validate lung cancer biomarkers in saliva. The major goal is to perform a properly powered biomarker discovery and definitive validation of salivary proteomic and miRNA biomarkers for detection of lung cancer based on PRoBE design principles (prospective-specimen collection and retrospective-blinded-evaluation). The outcome of this three-year proposal will be a panel of definitively validated non-invasive saliva-based proteomic and micro-RNA biomarkers for detection of lung cancer.

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