Abstract
Background: A steady rise in incidence of oral cavity cancer cases among young males have given rise to a new risk factor, namely human papillomavirus (HPV). Objective: This study aims 1) to determine prevalence and association of HPV among oral cavity cancer patients and healthy local population. 2) to identify the association of HPV and other risk factors. Methods: This case-control study consists of a test group (oral cavity cancer patients) and a control group (healthy individuals) from July 2013 till June 2014 involving patients from 3 different institutions. HPV status was tested via salivary rinse samples collection and processed using Diacarta Quantivirus® HPV E6/E7 RNA assay. Results: This study involves 58 subjects (29 test subjects, 29 control subjects). HPV prevalence was found to be 55.1% among test subjects and 3.4% among control subjects. This was found to be significant (p=0.001) with odds ratio of 33.90 (95% CI 3.88, 295.99). Among the risk factors, smoking habit was seen in 51.2% of test subjects and 13.8% of control subjects. This association was found to be significant (p=0.041) with odds ratio of 4.36 (95% CI 1.06, 17.86). Alcohol consumption and betel nut chewing were found to be insignificant in this study. Conclusion: HPV prevalence among oral cavity patients was found to be high and this demonstrates HPV infection is now an established risk factor in this country. Smoking habit was also found to be a significant risk factor among these patients and did not interact or confound the factor of HPV infection.
Published Version
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