Abstract

Saliva as a Diagnostic Fluid for Neurological Disorder

Highlights

  • Diagnosis of neurological disorders is critical to prevent complications and negative impact on the quality of life of patients

  • Evaluation of saliva is potential in developing the non-invasive diagnostic test for the discovery of disease biomarkers, but the value and applicability of saliva in biomarkers discovery for the diagnosis of neurological diseases remains in question

  • The existing research remains in the evolution phase in discriminating the reliability of salivary biomarkers for early detection of neurological conditions

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Summary

Introduction

Diagnosis of neurological disorders is critical to prevent complications and negative impact on the quality of life of patients. Due to various factors including lack of awareness, resource deficit, and social circumstances, several diseases are misdiagnosed until a late phase To deal with these problems, researchers are investigating biomarkers that reflect the pathological state of an individual that helps in understanding the underlying cause of the disease [1]. Metabolite identified by metabolomics study is considered feasible and would be reliable biomarkers for the disease This could be useful in understanding the biochemistry of the disease by knowing the biological process of individual metabolites and their correlation with the metabolic pathways involved in the disease. It may help the neurologists and pharmacologist in better clinical management. The related study in saliva using metabolomics techniques for NDD are summarized (Table 1)

Method
70 AD 51 PD
Findings
Conclusion
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