Abstract
Three salicylate derivatives i. e. sodium salicylate, acetylsalicylic acid and salicylsalicylic acid were tested and compared in A/Jax mice with regard to their effect on foetal damage on day 17 of gestation. The substances were administered by stomach tube in a dose constituting 2/3 of the LD50 dose in adult mice. Twentyfour hours after administration of each of the three derivatives an increased incidence of foetal death and haemorrhages were found. The highest incidence was found in the acetylsalicylic acid treated group. Four hours after administration all the salicylate derivatives caused a reduction in foetal liver glycogen. The control suspension however, also significantly reduced the glycogen content. The results are discussed in relation to the recommendations for drug testing. The advantage of comparing different drug derivatives for the study of the underlying mechanism responsible for their pharmacological actions is emphasized.
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