Abstract
The anti‐inflammatory effect of acetylsalicylic acid, salicylsalicylic acid, sodium salicylate and salicylamide was investigated by means of the carrageenin‐induced oedema‐test in rats. Salicylamide in these experiments was found to be significantly less effective than the other compounds tested. With regard to the effect on 35S‐sulphate incorporation into calf rib cartilage in vitro salicylsalicylic acid was superior to the other compounds as it had an inhibitory effect of 70 % as compared with about 45 % for acetylsalicylic acid and about 35 % for salicylamide. The analgesic activity was investigated using the phenylquinone‐method on mice. Acetylsalicylic acid was found to be more active in this respect than the other salicylates. Gastric irritation was studied on the gastric mucosa of guinea‐pigs. After sodium salicylate and acetylsalicylic acid administration the mucosa became hyperaemic and in addition acetylsalicylic acid caused numerous erosions in the stomachs. Neither salicylsalicylic acid nor salicylamide gave any significantly increased rate of gastric irritation in the guinea‐pigs.
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