Salep Ekstrak Daun Kersen Meningkatkan Kepadatan Kolagen dan Mempercepat Penyembuhan Luka Sayat pada Kulit Mencit Hiperglikemia

Abstract

This study aims to determine the effect of Muntingia calabura‘s leaves extract ointment on the healing of cuts in the skin of hyperglycemic mice in terms of collagen density. This study used 24 male mice (Mus musculus) with alloxan induced hyperglycemia (150 mg/kg body weight) intraperitoneal. Skin incisions are made on the back using a scalpel with a length of ± 15 mm and a depth reaching the subcutaneous. The experimental animals were randomly divided into four treatments and each treatment consisted of six replications, namely the control was given a placebo, and the treatment of cherry leaf extract ointment with a concentration of 30%, 40%, and 50%. The process of wound healing was observed histopathological with collagen density parameters. Based on the results, there was an increase in collagen density in each treatment. The mean collagen density in treatment (T) 0% (T0) 0.60; at treatment 30% (T1) 0.73; at treatment 40% (T3) 1,46; at 50% treatment (T3) was 2.20. The results of the study through the Kruskal Wallis test stated that the cherry leaf extract ointment had a very significant effect on the healing of the incision wound of hyperglycemic mice as seen from the density of collagen. We conclude that the administration of 50% cherry leaf extract ointment is the most effective in accelerating the healing of the hyperlycemic mice incision wounds in terms of collagen density.