Abstract
Dysregulation of neuronal stress response signaling has been implicated in neurodegenerative pathologies and is an emerging target for drug discovery. Sage was previously reported to beneficially modulate stress response signaling in C. elegans and may have therapeutic potential in Alzheimer's disease (AD) and Parkinson's disease (PD). The objective of this investigation was to evaluate the in vivo neuroprotective effects of sage extracts in experimentally induced neurodegeneration in C. elegans. For AD, time to thermally induced Aβ1–42 aggregation mediated paralysis was evaluated in transgenic C. elegans (CL4176). For PD, MPP+ induced neurodegeneration was qualtified by loss in motility and degradation of GFP signal in wild type and transgenic C. elegans. Evaluation with fractionated sage extract characterized by HPLC/DAD/ELSD/MS suggests polar acidic fraction to be most effective and reduced Aβ1–42 induced paralysis by 15%. In the MPP+ induced neurodegeneration for PD, bioactive compounds in polar acidic fraction were most effective and decreased paralysis in wild type worms by 17%.Grant Funding Source : VRDÜR FOUNDATION
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