Abstract
We previously reported that polar fractions of cinnamon may have therapeutic potential in Alzheimer's disease (AD) and Parkinson's disease (PD). The objective here was to evaluate the in vivo neuroprotective effects of polar bioactive compounds (10‐25 mg/ml of Sodium Benzoate, Cinnamic Acid, Cinnamaldehyde, Cinnamyl Acetate, Ethyl Cinnamate and Procyanidin B1) on experimentally induced neurodegeneration in C. elegans and D. melanogaster. For AD, time to thermally induced Aβ1–42 aggregation mediated paralysis was evaluated in transgenic C. elegans (CL4176). For PD, MPP+ induced neurodegeneration was qualtified by loss in motility and degradation of GFP signal in wild type and transgenic C. elegans. In drosophila, neurodegeneration was induced via the UAS/GAL4 tissue‐specific expression system and neurotoxicity was induced via exposure to rotenone (0.5 M ) and scored for locomotion, and geotaxis. Results suggest that treatment with bioactive compounds caused statistically significant (p < 0.05) amelioration (12‐30%) in markers of neurodegeneration and neurotoxicity both C. elegans and D. melanogaster.Grant Funding Source: VRDÜR Foundation
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