Abstract
Due to the safe "off label" use of selected antiparasitic drugs in fish, weassessed the effects ofatherapeutic bath with levamisole (50mg/l), fenbendazole (25mg/l), and ivermectin (0.031mg/l) onthe haematological and biochemical blood indices, oxidative and antioxidant variables, and gill histology ofthe common carp (Cyprinus carpio). Levamisole did not affect the haematological profile, but significantly increased (P<0.01) the plasma glucose, lactate, and ammonia concentrations, alkaline phosphatase, and alanine aminotransferase activities, TBARS (muscle, liver), total superoxide dismutase activity (muscle), and catalase activity (liver) and significantly decreased (P<0.01) plasma aspartate aminotransferase and glutathione reductase activity (gill, liver, muscle). Ivermectin led toasignificantly (P<0.01) greater muscle total superoxide dismutase activity compared tothecontrols, whereasthe haematological and biochemical indices remained unchanged. Onthe other hand, fenbendazole did not affect the haematological orbiochemical indices, and the oxidative stress parameters and antioxidant indices did not differ from the controls. The bath in FBZ can be recommended for safe antiparasitic treatment in carp.
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