Safety and efficacy profile of povidone iodine pleurodesis in patients with spontaneous pneumothorax

Abstract

Introduction: Multiple agents are being used for the purpose of chemical pleurodesis with varied success and risks. Povidone iodine was also a successful agent in inducing pleurodesis in pleural effusions and pneumothoraces. Aims and Objectives: To evaluate the efficacy and safety of povidone iodine pleurodesis through intercostal tube drainage (ICD) in patients with spontaneous pneumothorax. Materials and Methods: This was a prospective study where povidone iodine was infused into pleural cavity through ICD in patients with spontaneous pneumothorax. Success of procedure and adverse events recorded. Patients were followed up for 12 months for recurrence of pneumothorax. Results: A total of 38 patients with mean age of 58.6 12.5 years were included in study. 28 patients had successful first procedure, six patients required repeat pleurodesis, three had failed pleurodesis and two had recurrent pneumothorax after 6 months. All patients experienced chest pain of varying severity. Two patients had ARDS. Conclusion: Povidone iodine can be used as effective and safe agent for chemical pleurodesis in spontaneous pneumothorax. Keywords: Pleurodesis, Pneumothorax, Povidone iodine, ARDS, Intercostal tube drainage, Talc.