N-terminal pro-brain natriuretic peptide current trends in diagnostics

Abstract

N-terminal pro-brain natriuretic peptide is the prime standard biomarker used for heart diagnosis and prognosis. Owing to the acute response and considerable half-life, the N-terminal pro-brain natriuretic peptide is the most reliable biomarker to identify a cardiac injury. N-terminal pro-brain natriuretic peptide can act as an independent risk factor for the COVID-19 infected patients, but the exact reason for raise in the level of biomarker is still unclear. Various immunological platforms like immunofluorescence, enzyme linked immunosorbent assay, lateral flow immunoassay, chemiluminescence immunoassay, stable isotope standards capture by anti-peptide antibodies assay are used to detect the N-terminal pro-brain natriuretic peptide from human blood. Chemiluminescence immunoassay lead the diagnostic platform for the determination of N-terminal pro-brain natriuretic peptide due to high stability, ultra-sensitivity, specificity, and high throughput.