Abstract
Purpose: Intestinal dysfunction is a major problem after gastroschisis repair, and causes poor oral intake and poor body weight gain in infants with gastroschisis. Dai-kenchu-to (DKT) is often used in the treatment of gastrointestinal dysfunction in Japan. The purpose of this study was to analyze the effect of DKT on infants with uncomplicated gastroschisis. Methods: In this retrospective cohort study from 1991 to 2009, we assessed 16 infants with uncomplicated gastroschisis. Eight infants received 0.3 g/kg/day of DKT for 12 months (group 1) and 8 infants did not receive DKT (group 2). We analyzed their body weight as an indicator of the effect of DKT. Results: There were no significant differences in the background characteristics. The body weight of group 1 was significantly increased at the ages of 9 months (p = 0.0348) and 12 months (p = 0.0097), compared with group 2. Multivariate analyses revealed that only DKT administration had a significant impact on body weight gain at the ages of 9 months (p = 0.0201) and 12 months (p = 0.0111). No side effects related to DKT were reported. Conclusion: DKT administration might work safely and effectively for improving the body weight gain in infants with uncomplicated gastroschisis.
Highlights
Gastroschisis is associated with abnormal intestinal motility and nutrient absorption, both of which gradually improve over time in most patients [1]
The reported incidence of gastroschisis ranges from 0.4 to 11.7 cases per 10,000 live births, and studies in Japan, the United States and Europe have indicated that the incidence has markedly increased in all maternal age groups over the past two decades [31,32,33,34,35,36,37,38]
Gastroschisis is a congenital condition with survival of greater than 90% [39], most patients with gastroschisis have initial gut dysmotility and require parenteral nutrition
Summary
The purpose of this study was to analyze the effect of DKT on infants with uncomplicated gastroschisis
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