Sa1962 THE HEMOSTATIC EFFECT OF MUSSEL-INSPIRED CATECHOL ADHESIVE SHEET AFTER MUCOSECTOMY INDUCED ULCER: PORCINE EXPERIMENT

Abstract

Gastrointestinal bleeding is the common problem in daily clinical practice. InnoSEAL Plus® is a sheet-type hemostat that is made of a mussel-inspired catecholic adhesive material. It can stop a variety of bleedings in a coagulopathy independent manner. The aim of this study was to evaluate hemostatic efficacy of the catechol-adhesive sheet on gastric ulcer bleeding on porcine model. In a total of 15 pigs, iatrogenic ulcer bleedings were made using endoscopic mucosal resection method. Five minutes before intervention the pigs were given full weight-adjusted heparin. Four ulcer bleedings (Forrest Ib) were made per 1 pig, and one of them was not treated as a negative control (NC) group. The other ulcers were treated with gauze compression (GC), argon plasma coagulation (APC), and InnoSEAL Plus® respectively. Initial hemostasis and recurrent bleeding were recorded. Initial hemostasis achivement at 2 minutes after the treatment was 14 of 15 (93.3%) with InnoSEAL Plus group while 1 of 15 (6.7%) of NC group, 2 of 15 (13.3%) of GC group, and 13 of 15 (86.7%) of the APC group. There was no recurrent bleeding in InnoSEAL Plus® group. Recurrent bleedings were occurred in NC group (n=2), GC group (n=1), and APC group (n=2) on day 1. One in APC group also showed recurrent bleeding on day 5. InnoSEAL Plus® has hemostatic efficacy to stop Forrest I b bleeding in pigs receiving anticoagulant therapy. This could be new endoscopic treatment for GI bleedings.