Abstract
was infused intravenously and both normal appearing tissue and the area of concern were imaged and recorded using the pCLE probe. The area of concern was then biopsied and the biopsies were read by a single pathologist. The pCLE images were examined by a single physician familiar with pCLE technology. Results: 12 patients were enrolled. Average age was 50 years. Five of the 12 patients had lesions with features of high grade dysplasia on biopsy (Anal Intraepithelial Neoplasia 2 or 3 (AIN2/3)). Normal squamous tissue was wellimaged in all patients in non-suspicious areas of control. Confocal findings in areas of concern included the following: 1) pleomorphic cells with loss of regular squamous architecture (5/5 patients 100%) 2) dark spots, potentially representing gland formation (3/5 patients 60%) 3) large or torturous blood vessels (4/5 patients 80%). 4) Dark bands (1/ 5 patients 20%). Quality of imaging was deemed adequate and interpretable in all patients with HGAIN lesions. Conclusions: Distinctive features on pCLE can be found in lesions suspicious for HGAIN in a population of HIV-infected males. If sensitive and specific, pCLE may obviate the need for anal biopsy allowing real-time treatment.
Published Version
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