Abstract
Hydrogen sulfide (H2S) has been recognized as one of the important gaseous cellular signaling molecules. H2S is considered to be involved in vascular relaxation, neurotransmission, and inflammation. To investigate the physiological and pharmacological actions of H2S, inorganic sulfide salts such as NaSH have been commonly used as H2S donors. However, these approaches suffer from an inability to precisely control the release rate and dosage. Although several H2S releasers have been reported, they are still incontrollable for H2S release except one example. To overcome these shortcomings, we focused on photochemical H2S generation. Controlled H2S release with photoirradiation has the potential to provide a high degree of control over release location, timing, and dosage. We envisaged that modification of H2S with suitable photolabile protecting groups would afford an H2S donor directly controllable with light, which would release H2S upon rapid photodissociation of the two protecting groups. A ketoprofenate photocage offers many advantages including good photochemical properties. In this study, we adopted ketoprofenate photocages for our new H2S photo-releaser, and developed a novel photocontrollable H2S releaser, which releases H2S proportionally to the photo-irradiation time and intensity. Photocontrolled H2S release from this compound was also demonstrated in biological bovine serum systems.
Published Version
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