Abstract
The P300 event-related potential (ERP) component is typically elicited during an oddball task by infrequent target or novel deviant stimuli (P3b and P3a subcomponents, respectively) that are randomly interspersed among frequent standard stimuli. Standard stimuli can also elicit a P300 if they are relatively unlikely to occur within local sequences of standards, as the implicit context created by local stimulus probabilities can render standard stimuli improbable and therefore, deviant. Previously, we showed that healthy individuals generate a P3a in response to low probability standards, yet chronic schizophrenia patients failed to generate this response. The present study examined P3a associated with standard stimuli in young patients with early illness schizophrenia (YSZ) and in individuals at clinical high risk for psychosis (CHR).
Published Version
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