S1389 The Impact of Race on the Overall Survival Rate of Hepatocellular Carcinoma in the African-American Population

Abstract

Introduction: Hepatocellular carcinoma (HCC) accounts for approximately 90% of the incidence of all primary liver cancers. It is also the fifth most prevalent malignancy worldwide and the fourth global leading cause of death. Previous U.S.-based studies on survival rates suggest ethnic disparities among HCC patients; however, this is incompletely understood due to a variety of risk factors. Notable risk factors include oncogenic viral infection with hepatitis B virus (HBV) or hepatitis C virus (HCV), alcohol abuse, and metabolic syndrome secondary to obesity and diabetes mellitus. This study aims to investigate whether race plays a role in the overall survival rate of hepatocellular carcinoma. Methods: Using the cBioPortal platform and systematic bioinformatical-analysis of The Cancer Genome Atlas (TCGA) PanCancer Atlas dataset, we analyzed the effect of race on overall survival rate. The study included 360 HCC patients (234 living patients and 126 deceased patients). The following races were included: White, Black or African American, and Asian. Results: The impact of race on the overall survival rate of hepatocellular carcinoma was statistically significant (p < 0.0206) and appeared to be higher in the African American group (64.71%) compared to the White (57.92%). Of note, the Asian group had the highest overall survival rate (73.13%). (Figure) Conclusion: The findings in this study suggest that race may play a role in the risk of developing hepatocellular carcinoma and potential treatment options. Further studies are warranted to evaluate the genetic alterations in various race groups.Figure 1.: Hepatocellular carcinoma overall survival among the African American, White, and Asian populations.