S128. Predicting Individual Responses to the Electroconvulsive Therapy With Hippocampal Subfield Volumes in Major Depression Disorder

Abstract

Electroconvulsive therapy (ECT) is one of the most effective treatment for major depression disorder (MDD). ECT can induce neurogenesis and synaptogenesis in hippocampus, which contains distinct subfields, e.g., the cornu ammonis (CA) subfields, a granule cell layer (GCL), a molecular layer (ML), and the subiculum. It is still unclear which of these subfields are affected by ECT in MDD. More importantly, can we predict the future treatment response to ECT by using volumetric information of hippocampal subfields at baseline?