Abstract
Antidepressants are often used to treat adolescent depression but the neural mechanisms underlying their action in the young brain are still poorly understood. Depressed adolescents have difficulties in regulating negative emotions, a symptom that has been associated with hypoactivation in the dorsolateral prefrontal cortex (DLPFC), a key region involved in cognitive control. The current study therefore aimed to assess the neural effects of fluoxetine on emotional regulation prior to changes in symptoms.
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