S0077 Probable Association of Idiopathic Pancreatitis With Smoking of Tobacco

Abstract

INTRODUCTION: Acute pancreatitis is a serious disease with high morbidity and mortality rates. Research shows that among the primary admissions for acute pancreatitis, 26.9% had gallstone pancreatitis, 25.1% had alcoholic pancreatitis and 36.5% had idiopathic pancreatitis. Idiopathic pancreatitis accounted for a higher mortality rate than both gallstone pancreatitis and alcoholic pancreatitis patients (Chen et al., 2013).1 Recent studies have shown that cigarette smoking can also be a risk factor of acute pancreatitis. The two main metabolites from cigarette smoke are nicotine and NNK, which cause histologic changes to the pancreas. There is also indirect evidence that nicotine and acrolein cause ductal secretion due to CFTR dysfunction. As mentioned above, this can be a direct cause of inducing an attack of acute pancreatitis (Barreto, 2016).2 METHODS: This study is a retrospective chart review of adult patients that would include all adults (age >18 years), both genders, of all ethnic backgrounds, adults presenting with symptoms consistent with acute pancreatitis. The rate of pancreatitis will be compared among tobacco smokers and non-tobacco smokers. The association between pancreatitis and tobacco use will be tested for significance at P < 0.05 with Chi-square analysis. The magnitude of the risk of use will be calculated using Odds Ratio. RESULTS: There was 301 total number of patients in the study. Mean age was 58.76 (SD: 14.13) years and predominantly male (n = 164, 54.5%). There is a 2.32 (odds ratio) higher risk of acute pancreatitis and a smoker. This study showed a significance of P-value <0.0001 between idiopathic pancreatitis and tobacco use. CONCLUSION: Tobacco use is a risk factor for chronic pancreatitis but has not been associated directly with acute pancreatitis previously. There were multiple case reports in the literature that reported tobacco use associated with acute pancreatitis. This study has shown a significant association between tobacco use and acute idiopathic pancreatitis.Table 1.: smoking_use * idiopathic_acute_pancreatitis CrosstabulationTable 2.: Chi-Square Tests