Abstract
Herein, S, N doped carbon quantum dots (S, N- CQDs) were prepared by a simple hydrothermal method and characterized by transmission electron microscopy (TEM), Energy-dispersive X-ray spectroscopy (EDS) and Fourier transform infrared (FTIR) analysis. The influence of as-prepared CQDs was studied on the luminol- Mn(IV) CL reaction. The results indicated that S,N-CQDs remarkably increase the CL intensity of this reaction (about 13 fold). Furthermore, it was found that the CL intensity of S,N-CQDs–luminol-Mn(IV) system was significantly declined by uric acid. We exploited the amplified CL system to design a novel probe for the detection of uric acid. The CL intensity of S,N-CQDs–luminol-Mn(IV) reaction was proportional to the logarithm of uric acid concentration in the range of 0.05 to 1.5 µM, with a limit of detection of 17 nM. Based on these results, a sensitive and straightforward CL method was developed for the analysis of uric acid in biological fluids with satisfactory results.
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