S.27.03 - Anticipation and dynamic mutations in psychiatry

Abstract

Listen

Translate article

Some recent finding report that the area 5q11.2–13.3 of chromosome 5 segregates with schizophrenia in an uncle-nephew pair (Bassett et al 1988). However, linkage studies between chromosome 5 markers loci and schizophrenia lead to different results: Sherrington et al (1988) found a positive linkage, whereas other groups of researchers found evidence against linkage (Kennedy et al 1988; St. Clair et al 1989; Detera-Wadleigh et al 1989; McGuffin et al 1990; Aschauer et al 1990; Crowe et al 1991). We have studied five Italian pedigress segregating schizophrenia using a map of four markers for the chromosomal region 5q11.2–13.3. Linkage analyses revealed negative lod scores, and thus no evidence for linkage was obtained in our Italian families.