Abstract
This study was designed to investigate the effects of rutin (RT) and ascorbic acid (AA) combination on oxidative stress‐induced by high‐cholesterol‐diet (HCD) supplementation in the kidney of female Wistar albino rats. Feeding cholesterol increased serum total cholesterol (TC), triglycerides (TG), LDL and decreased HDL levels as compared to control diet. Treatments with RT, AA and their combination significantly decreased the TC, TG and LDL levels while increasing HDL levels. Nucleic acids (DNA and RNA), total protein and GSH concentrations were significantly decreased while TC, TG and TBARs levels were increased in kidney tissues of hypercholesterolaemic diet‐fed rats. The supplementation of RT and AA combination brought back the changes‐induced by the HCD to normal level. However, the correction of changes in all parameters showed more significant in RT and AA combined therapy than the individual treatments. These results suggest that the supplementation of RT (vitamin‐P) and AA (vitamin‐C) promoted the excretion of fecal sterols, thereby leading to a decreased absorption of dietary cholesterol as well as lower plasma and tissues cholesterol.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
