Rutin Mediated Synthesis of Silver Nanoparticles derived from Melia dubia and Evaluation of Antioxidant and Antimicrobial Activity

Abstract

Researches based on bio inspired synthesis of noble metal nano materials has become a promising one in today’s biomedical approach in therapy and diagnosis due to multidimensional applications. Furthermore, silver nanoparticles were reported to have several medicinal applications. Hence the present study was to explore the antioxidant and antimicrobial efficacy of silver nanoparticles (AgNPs) synthesized from rutin isolated from the methanolic extract of leaves of Melia dubia. The biosynthesized nanoparticles were analyzed using UV-Visible, FT-IR, XRD and SEM techniques. The band at 398.5nm in the UV-Visible spectra confirmed the formation of AgNPs. The characteristic shift in OH and C=O peak after the formation of silver nano particles shows the participation of biomaterial (Rutin) in the reduction process which is further supported by SEM report. The average size of the particle (19 nm) was determined from XRD analysis using the Scherrer’s equation. The antimicrobial and antioxidant efficacy of harvested nanoparticles were compared for their potential with rutin and silver salt. The synthesized material was shown to have good antimicrobial activity towards the tested bacteria and fungi and potentially active towards free radicals. Thus, the silver nanoparticles (AgNps) synthesized using bio-flavanoid viz. rutin are potentially good and therefore can be further studied for pharmacological activities.