Abstract
Antioxidant and anti-proliferative activities of Sabah Ruellia tuberosa Bo Eng Cheong, Mohd. Zulkarnain Waslim, Fui Fui Lem, Peik Lin Teoh
Highlights
Drug-induced nephrotoxicity is a serious kidney problem and is responsible for a variety of pathological effects on the kidneys (Sarang and Ameeta, 2001)
DEN-administration resulted in marked impairment of kidney function as demonstrated by the significant increase in serum urea (P
Oral administration of either R. graveolens or rutin to DEN-treated rats significantly decreased the elevated levels of serum urea, creatinine and uric acid when compared with the DEN control group
Summary
Drug-induced nephrotoxicity is a serious kidney problem and is responsible for a variety of pathological effects on the kidneys (Sarang and Ameeta, 2001). R. graveolens has been extensively used in treatment of vitiligo, psoriasis, leucoderma, multiple sclerosis, cutaneous lymphomas, and recently reported to possess anticancer, anti-inflammatory, hepatoprotective and antidiabetic activity (Pathak et al, 2003; Preethi et al, 2006; Ahmed et al, 2010; Mahmoud et al, 2014). It has been used for gastric disorders, stiff neck, dizziness and headache (Conway and Slocumb, 1979); its protective effects against DEN-induced nephro-toxicity were not reported
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