Abstract
Nephropathy is a microvascular complication of anti-tuberculosis therapy that can disturb treatment and cause permanent kidney damage.The current study was designed to evaluate the possible protective effects of Prunus armeniaca leaves extract against isoniazid (INH) and rifampicin (RIF)-induced nephrotoxicity in rats. The experimental rats received INH and RIF at dose level of 50 mg/kg, and either 100 mg or 200 mg/kg body weight Prunus armeniaca leaves extract orally for 45 days. INH/RIF administration induced nephrotoxicity evidenced by the histopathological alterations as well as significant (P < 0.001) increase in serum urea, creatinine and uric acid. INH/RIF-intoxicated rats exhibited a significant increase in serum tumor necrosis factor alpha (P < 0.01) and renal lipid peroxidation levels (P < 0.001). Conversely, reduced glutathione content, and activity of superoxide dismutase and glutathione peroxidase were significantly declined in kidney of INH/RIF-induced rats. Concomitant supplementation with either dose of Prunus armeniaca leaves extract prevented the INH/RIF-induced biochemical and histopathological alterations. In conclusion, the present study confers new information on the protective effect of Prunus armeniaca leaves extract against anti-tuberculosis therapy-induced nephrotoxicity. Prunus armeniaca protect against INH/RIF-induced renal injury through abolishment of inflammation and oxidative stress, and potentiation of the antioxidant defense system.
Highlights
Tuberculosis (TB), a serious disease caused by Mycobacterium tuberculosis, is a growing international health concern[1]
It has been reported that nephropathy is an important microvascular complication of anti-tuberculosis therapy[23]
Multiple studies have reported that oxidative stress and inflammation are implicated in drug-induced organ toxicity[5,24]
Summary
Tuberculosis (TB), a serious disease caused by Mycobacterium tuberculosis, is a growing international health concern[1]. It has been reported that the use of isoniazid and its combination with rifampicin is associated with liver damage that could result in acute liver failure with a high mortality rate[4,5] The rate of their hepatotoxicity is much higher in developing countries compared to that in developed countries, even with using the same dose schedule[6]. Nephroprotective effect of apricot leaves extract tributed in plants, could be useful in protecting against drug-induced nephrotoxicity[10]. The present study was designed to evaluate the protective effects of Prunus armeniaca leaves extract against INH and RIF-induced renal injury in rats
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