RUSS-AGE: developed research protocol for the creation of Russian biological age calculators

Abstract

Background. Life expectancy is increasing around the globe. However, chronological age is not the best indicator of health. For a more accurate assessment of body condition throughout life, in general, and aging, in particular, and identify potential points of geroprotective intervention, a specialized tool is needed. A tool that could prove beneficial is a biological age calculator, utilizing a range of biomarkers to analyze the degree of functional preservation of the body. Many existing biological age calculators are limited by a small number of parameters to analyze and sensitivity to use in a specific population.Aim. Large-scale studies to create a mathematical model for calculating biological age based on the Russian population have not previously been carried out. In 2022, the RUSS-AGE study was launched to create biochemical, cognitive and microbiotic calculators of biological age and determine possible points of geroprotective interventions.Materials and methods. The study intends to enroll at least 3,500 participants and analyze more than a hundred biomarkers using laboratory tests, questionnaires, neurocognitive and functional testing, and collection of anthropometric and physical indicators.Results. Currently, the recruitment of participants is supported by a government grant under the Priority 2030 program. By November 2023, 510 participants had been enrolled in the study.Conclusion. Further statistical processing of the information received and the development of prototypes of biological age calculators are planned.