Abstract
Purpose We compare the bacteriological and clinical efficacy of rufloxacin and ciprofloxacin in patients with acute uncomplicated pyelonephritis. Materials and Methods A total of 110 outpatients was enrolled in a randomized, double-blind multicenter study and treated for 10 days with 200 mg. rufloxacin daily (after a loading dose of 400 mg. on day 1) or 500 mg. ciprofloxacin twice daily. Bacteriological and clinical efficacy was based on the accumulated outcomes assessed at the end of treatment, and at 2 and 4 to 6 weeks. Results The bacteriological and clinical success rates of rufloxacin and ciprofloxacin were comparable: 55.6 percent versus 58.8 percent and 74 percent versus 71 percent, respectively (95 percent confidence interval -28 percent to +22 percent and -20 percent to +25 percent, respectively). Both study medications were well tolerated. Conclusions Rufloxacin once daily is a good alternative in the outpatient treatment of acute uncomplicated pyelonephritis.
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